Embryonic And Induced Pluripotent Stem Cells Biology Essay

Embryonic And Induced Pluripotent Stem Cells Biology Essay INTRODUCTION: Stem cells are cells which are found in almost all multicellular organisms. Stem cells was proposed by a histologist Maksimov. A in 1908. They develop into many different types of cells in the body during their early life and growth and serve as a internal repair system in many tissues. Formation of new cells can be seen when stem cells division starts these new cells can either form a stem cell or other types of cells like muscle cells,brain and red blood cells with specialized functions. Stem cells are the objects in biomedical research and are differentiated from other types of cells by two main characteristics. Firstly, Stem cells are the undifferentiated cell types they possess the capacity of both self renewable during cell division. Secondly, Potency which means they can be differntiated into differnt types of specialized cells with specific function.(Bishop et.al., 2002). Stem cells can be totipotent and pluripotent. In some organs like gut or bone marrow the st em cells divide either to replace or repair the damaged or worn out tissues while in other organ system like pancreas they divide under some specific function Totipotent stem cells can give rise to a functional organism as well as to every cell type of the body. Pluripotent stem cells are capable of giving rise to any tissue type, but not to a functioning organism. Multipotent stem cells are more differentiated and thus can give rise only to a few tissue types. For example, a specific type of multipotent stem cell called a mesenchymal stem cell can produce bone, muscle, cartilage, fat, and other connective tissues. (Pittenger et.al., 1999). They are two types of Stem cells 1) Embryonic stem cells 2) Adult stem cells also known as somatic cell or tissue specific. Embryonic stem cells are derived from the blastocysts and are pluripotent instead of totipotent because they do not have the ability to become part of the extra-embryonic membranes or the placenta while the adult cells are present in adult tissues while the stem cells found in developed tissues are the Adult stem cells and the example for this is the hematopoietic stem cells of blood which cannot give rise to the cells of a different tissue, such as nerve cells in the brain (Frankel et.al.,1999). The difference between between embryonic and adult stem cells(somatic) is their origin that is embryonic cells can differntiate into any c ell types but adult stem cells are limited and can differentiate into the cells of their own tissue by this the grown cells wont be rejected by the immune system during treatment and these cells also differ by mutation frequency (James et.al.,2002). The stem cells derived from the human embryo is known as Human embryonic stem cells and these cells are for reproductive purpose. While, in 2006 researchers have observed new type of specialized adult cells this cells are called as Induced pluripotent cells (iPSCs). Parthenogenetic stem cells are also one type of stem cells derived from activated human oocytes USES: Stem cells are useful in treating diseases like diabetis and heart diseases and many works are being done on how to use stem cells for cell based therapies in treating diseases which is also called as regenerative medicine. Stem cells have the ability to replace the damaged cells and can be used in treating heart failures. spinal injuries and parkinsons diseases for example, neural stem cells are able tp regenerate nerve tissue damaged by spinal injury. Stem cells are useful in screening toxins in substances such as pesticides and also used during development of new methods for gene therapy that may help those who are suffering from genetic illiness. They are also used in pharmaceutical industry for testing the new drugs before testing on animal and humans. Induced pluripotent cells are the adult stem cells have been genetically remodelled to an embryonic stem like to express genes and factors which maintains the properties of embryonic stem cells. EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLS: Embryonic stem cells are from the earliest stages of human embryo that develop into eggs by invitro fertilization while other embryos are developed for research and extracted after five days growth. It is known that embryonic stem cells divide indefinitely so only a single embryo can form lines of cells to use for treatment.(Thomson et.al.,1998) These cells are undifferentiated but has a ability to differentiate into any cell, tissue or organ in the body. These stem cells can also become nerve, muscle cells or any other type of human cells. The process involved in formation of ES cells is the ovaries are removed and after 76hours of copulation they are treated with media containing serum overnight.The following day the inner cell mass of embryos are removed and cultured on fibroblast after few weeks colonies grew which showed pluripotent characters referred to as ES cells. Embryonic stem cells are used to treat a host of diseases, such as Parkinsons disease, spinal cord injury, and d iabetes (Martins.,1981). For research, these embryos are destroyed in the process of deriving embryonic stem cells. ES cells have got a great potential for long term therapies but the issue arises regarding safety. Transplanted ES cells have uncontrolled growth and could generate tumours which is seen in laboratory cultures by scientists and there are not sure how they behave inside the body. So, this is to be studied before proceeded in clinical trials while another issue is tissues derived from the ES cells are rejected by patients immune system after transplantation. To overcome this issue tissue rejection currently, drugs can be used which suppresses the immune system but these drugs can be infectious thus drugs without any side effects are being investigated by the researchers or alternatively adult stem cells can be used. The major issue is in process of extracting the embryonic cells the embryos have to be destroyed this is opposed by many people and raises ethical issues. Al ternatives are being investigating by combining the stem cell technology with cloning by a method called (SCNT) somatic cell nuclear transfer.(Stewart et.al.,2007). It is a method which involves insertion of the nuclei of the somatic cell into the oocyte which develops into the embryo. This embryo derives the embryonic stem cell lines which is carried out in several mammalian species but till date No ES cells have been successfully developed by this method and also requires destruction of many embryos compared to other methods. And the other issue by usig this method is therauptic human cloning would lead to reproductive human cloning which leads to maral and social danger. The use of ES cells got many ethical issues as it is derived by destroying the embryos which raises fundamental concers of human life. (Tabar et.al.,2001). Problems associated with stem cell research according to the researchers embryonic stem cells are known for the cell baesd therapies as they are more versatile than adult stem cells but the same properties of these cells make them unusual for therapy as these will migrate all over the body and produce tumours. Growing and maintaining embryonic cell lines prove that they are problematic by performing experiments in mice as some of these get mutated and unusable to the patients. To overcome this problem adult stem cells acan be used to eliminate mutation tissue incompatibility. The pharmaceutical companies could not puruse these therapies due to financial incentives ( Phimister and drazen,2004). Recent advances in stem cells have new applications possible for stem cell based technology. It is now possible to reprogram differentiated human somatic cells into pluripotent cells that are functionally equivalent to embryonic stem cells. In 2006, specialized adult cells are been reprogrammed genetically to assume a stem cell like state called as Induced pluripotent stem cells. (Fenno.et.al., 2008). The use of ES cells as an alternative to oocytes which can be reprogrammed as an Human somatic cells. This can be done by fusion of human embryonic stem cells with fibroblasts which results hybrid cells.(Cowan et.al.,2005). These cells exhibits morphology and growth proper of embryonic stem cells and also express their genes. Transplantation of induced pluripotent cells into mice resulted in tumour containing variety of tissues on injection into the blastocyst showed mouse embryonic development This shows that Induced Pluripotent stem cells can be produced from fibroblast on addition wi th defined factors like oct3/4,Sox2 and klf4(Takahashi and Yamanaka.,2006). Researchers have demonstrated a novel technique for production of IPS cells by transforming Adult Skin cells which is considered as a fast reliable and safe method, viruses were used to insert the specific genes into the adult cell would result in increased potential for adverse outcomes and also increases the chance of genetic defects thus it would affect the patient treating with stem cell therapy.(Soldner et.al.,2009) Thus, alternatively transgenes or reprogramming proteins can used for insertion to overcome the risk and after induction using protein factors or virus free factors that can be removed to induce pluripotency which develops into IPS cells that does not have any risk.(Kaji et.al.,2009) As, IPS cells also raises ethical problems related to germline alterations. However using virus free factors can overcome the problem of germline alteration. In 2010, researchers have used Induced pluripotent stem cells to treat rodents suffering with parkinsons disease and this research was successfull this is done by transplanting the induced pluripotent cell neuron into the rodents mid brain injury which is similar to Parkinsons disease in humans by this the cells became functional and showed improvement. Thus induced pluripotent cells may be useful for future disease models and cell-based therapies. Induced pluripotent stem cells offer immense potential for regenerative medicine and studies of development and diseases. Thus analysis of genomic transcriptional activity, gene activation, allele specific gene expression and DNA methylation shows that the somatic cell was reprogrammed to an embryonic state which provides a system for investigating the mechanisms. To Induce pluripotent somatic properties which are similar to ES cells properties is done by introducing active genes or derivatives of RNA or protein products into the somatic cell but this process of acquiring pluripotency is not genetically but involves Epigenomic Reprogramming. There are differences between ES and IPSC cells regarding chromatin structure and gene expressionby showing few similarities while the other reports show that there is epigenetic differences and alteration. Reprogramming of a somatic cell into pluripotent state requires complete change of Somatic cell to an ES cell like state but this is not repo rted yet. On performing genomic profiling of the DNA methylomes of both ES and Induced pluripotent cells similarities are seen but every single line shows different reprogramming variability compared to both ES cells and other Induced pluripotent stem cells. Patterns of DNA methylation are seen as epigenetic change at the tips and centromeres of the chromososmes and show differences in CG methylation and histone modifications. Thus, Induced pluripotent cells may not be suitable substitute for embryonic cells. (Lister et.al., 2011). CONCLUSION: Human embryonic stem (ES) cell research has been the best way for the cell-based therapies for a number of diseases but the issue raises with destroying the embryos to produce these cells. The use of IPS cells has less ethically problematic than the use of Embryonic cells as production Of IPS cells does not require destroying the embryos. But the use of induced pluripotent cells raises ethical concerns to somatic cell reprogramming as there is a difference seen between the ES and Ips cells and the debate over stem cell therapy is increasingly becoming irrelevant but ethical issues regarding the Embryonic stem cells would not entirely go away.So, the study of all the types of stem cells should be done as it is not known which is useful for the cell replacement therapticus.

Human Evolution In Africa :: essays research papers

Evolution In Africa   Ã‚  Ã‚  Ã‚  Ã‚  Humans, as we consider ourselves, evolved in Africa. Not entirely, but from early primates to our present state. Many people dispute this fact, despite astounding evidence supporting the theory, for various reasons. Showing all the genetic, paleological, and geological proof, I find it very hard indeed to contradict the evidence.   Ã‚  Ã‚  Ã‚  Ã‚  True, humans didn’t evolve entirely in Africa. As a matter of fact the first known ancestors of humans where found in North America, in the Utah Valley. These animals where nothing more than a shrew in the shadow of the dinosaurs. However, with the event that killed the dinosaurs, they where finally allowed to reproduce and spread. At this time, according to isotope dating, the world was averaging 4 times warmer than it now is. As time went on, the small mammal had spread throughout Eurasia. All of Eurasia then was covered in tropical forests. Primates evolved in what is now the Indian Subcontinent.   Ã‚  Ã‚  Ã‚  Ã‚  From their placement in India, then still lowland, primates spread throughout the world once more. Some returned to North America, only to be wiped out by rodents already living there. Others spread to Europe and the Middle East.   Ã‚  Ã‚  Ã‚  Ã‚  By this time, Africa had just split from marsupial overrun Gondwanaland. About a million years later it reached the Middle East, and primates moved in. By now the world had cooled enough that the primates in Europe had been decimated to near extinction. They also migrated south, for the Mediterranean Sea was at that time dry lowland. Now almost all of the primates left in the world were in Africa, and the only marsupial that wasn’t wiped out was the opossum. Primates and large cats now ruled, with rodents scarce, which meant that the primates had to adapt to keep from becoming lunch. In light of this, natural selection shows only those primates with larger bodies and higher intelligence survived.   Ã‚  Ã‚  Ã‚  Ã‚  The once rodent sized primates, lemurs, now only exist in Madagascar, which had separated from Africa in the early Eocene Epoch, and where there were no predators to be found. In most of Africa, however, the primates got larger. They shifted evolutionary gears to start becoming apes and hominids. The first apes to evolve, Afropithecus was very small by ape standards. They were dumb tree swingers, but it was by their appearance that we owe our existence, along with chimps, gorillas, and orangutans. These apes, despite their stupidity, were very successful and spread back to India once more.

Obamacare Cons Essay

Even though ObamaCare does a lot right, it does have some consequences for specific groups of Americans. ObamaCare does hurt a small percentage of small businesses, has had a negative effect on insurance premiums and has made some reforms that have hurt some medical industries and their workers. Here are some of the cons of the healthcare bill: ObamaCare Cons: Taxes on Small Business  2% of firms in the US have over 50 full-time employees and will have to choose to insure full-time workers or pay a fine. To avoid this some businesses will cut employee hours or not hire. Some things worth noting are that the fine isn’t paid for your first 30 workers. Also, many businesses are coming up with solutions that don’t hurt the workforce such as passing the extra costs onto consumers. Please be aware that when politicians say, â€Å"small business† they are also referring to the top 3% of small businesses who include Hedge Funds which use loopholes to pass as small businesses. ObamaCare Cons: Religious Beliefs There is some argument over ObamaCare funding women’s health services like contraception. There are exceptions built into the law to refuse to provide these services to women based on religious grounds, but this has non the less been causing issues on the ground, in the political arena and in the courts. ObamaCare Cons: Rising Premiums ObamaCare doesn’t raise premiums itself. In fact, it reforms the insurance industry, finding ways to drive down costs, make the quality of insurance better and prevent insurance company abuses like . Unfortunately, many provisions of ObamaCare that offer protections to consumers do not go into law until 2014. In the meantime, premium rates have been rising at alarming rates. ObamaCare doesn’t offer a protection beyond allowing states to enact the provision against price gouging. Many States are enforcing this, while  others aren’t. ObamaCare Cons: ObamaCare Insurance Exchanges Another con of ObamaCare is that 21 states planning to or are opting out of the State Run Exchanges, letting the federal government run their exchanges for them. The claim is that this is a cost cutting measure for the State, however the truth is much more complicated. This provision was meant to be in the bill, but it is being abused as a way to avoid providing subsidies to low and middle income Americans and forcing the Federal taxpayers to take care of anti-ObamaCare state’s constituents. This has resulted in a 3.5% fee for insurance companies to sell insurance on the federal exchange. Learn more about the State Run Insurance Exchanges. ObamaCare Cons: Tax for Not Buying Insurance Come 2014, you must purchase insurance or pay a â€Å"penalty income tax†. The first year it is $95 or 1% of your income. In order for the program to work at its best ideally everyone would have insurance resulting in affordable quality insurance for all, the tax helps offset the estimated 6 million people will pay the fine in the first year instead of purchasing insurance. ObamaCare Cons: Big Business Taxes Medical device taxes and â€Å"drug innovator† taxes dig into the profits of some of the power houses in their respective industries. These taxes are a reaction to the large profit margins these companies have and the hold they have over the competition. They drive up the cost of health care, thus they are taxed to help pay for health care reform. However, taxes on large businesses may have unintended consequences in the job market and in aspects of the health care industry. We don’t have proof of their effects yet. ObamaCare Cons: Taxes on the 2% The top 2% of businesses and individuals in the US will pay some extra taxes.  You could argue that are closer to the 3% will get hit the hardest because the have the least extra cash to stay in the game with so it hurts them more. However, the most vocal opponents and the ones who fund the anti-ObamaCare campaigns are the big businesses who don’t like regulation, entitlement programs or any tax or program that affects their bottom line. Aside from the above mentioned consequences its important not to make their interests our own. ObamaCare Cons: ObamaCare Hurts Medicare ObamaCare cuts $716 billion from Medicare and reinvests the money back into the program. Since there is such a big overhaul ObamaCare set up a committee to oversee spending and effectiveness. Due to the sheer volume of reforms some of them, even though well intentioned, are sure to have unintended consequences and need adjusting. Although ObamaCare has already helped tens of millions of seniors save money on drugs and get access to better health care, there are some caveats. ObamaCare is projected to cost $1.1 trillion over the next ten years, and in order for the program to work as intended this is going to include funding from the tax payers and from the States. However, the end result of ObamaCare’s spending is a $200 billion dollar reduction of the deficit over the next decade, states also receive between 90 – 100% of funding for most ObamaCare related programs they set up. A few states, including Nevada and Michigan, have done studies that show how the States can save billions with ObamaCare. Health Insurance companies stand to make billions, despite a loss on profit per plan, since they will be insuring millions of new Americans.

Autobiography of a 15 Year Old Essay Example

Autobiography of a 15 Year Old Essay Example Autobiography of a 15 Year Old Essay Autobiography of a 15 Year Old Essay Essay Topic: Autobiography of My Mother On 24th April 1998. merely earlier midnight. the female parent of a four twelvemonth old who had been due for the 3rd of May. felt like her 2nd kid was ready to come in the universe. but her father in-law. who had been among the most honorable doctors of the twenty-four hours. declared it to be false hurting. When the state of affairs got serious. she was eventually admitted. and gave birth to a male child. which was much to the captivation of her male parent in-law. who. now holding two grandchildren. could anticipate at least one of them going a physician in the hereafter. The male child was named Siddhant. and was the newest add-on to the Passey household. I must acknowledge that I had a really safe. and unafraid childhood. much like the dream of most. My male parent. Dr Rajiv Passey. who had given his really last test on the 24th. a twenty-four hours before my birth. was on the brink of a successful calling in cardiology. I have learnt a batch from him in the 15 old ages and 2 months of my being. but I shall come to that subsequently. My female parent. Dr Sarita Passey had been learning organic chemical science for the past 4 old ages and has become a good honoured associate professor today. She has been non merely an inspiration. but has inculcated in me assorted things about life on this planet. My brother. Rohan Passey. who is about five old ages senior to me. was in the same school as I between 6th and 12th criterion and is now making electronics and instrumentality technology from Birla Institute of Technology and Science. Pilani. While both my parents state me continuously that I have taken after merely his worst qualities. I believe that is non true. and he has been one of the most illustrative characters of my life. I have ever been told that I am a spot more cognizant for my age. whether in footings of football cognition. or merely cognizing the exact specifications of all the popular smart phones available. and I accredit that to my brother. Interrupting a stereotype I must state. I have really few distinguished memories of my gramps. One of the oldest distinguishable memory that I possess is of my first twenty-four hours at Sardar Patel Vidyalaya. Of class. that was the twenty-four hours when I met some of the people who are my closest friends today. but I besides remember that I became friends with a individual in the coach who was a twelvemonth older to me and over the twelvemonth. we grew highly close. But when the following session of school started I did non see him in the coach. I was told that his male parent had been transferred from Delhi. and therefore he had changed schools. I feel really ashamed at myself today that I can non even retrieve his name. but the lesson I learnt so is that sometimes you have to allow travel of things. whether they be an intangible facet like friendly relationship. or a touchable thing like my first guitar. which I do non possess any longer. more on that later. In 2002. when I was 4 old ages old. we got our first computing machine. and that I started playing the game Fifa 2002. As usual. it was merely an imitation of what my brother used to make. This game holds huge importance in my life as it was merely through this game that I developed a liking/fancy for football. the athletics which has become a really crucial/momentous facet of my life today. While playing Fifa. I used to retrieve the names of all the participants and squads. and at that clip. an Italian squad. AC Milan became my front-runner. and its star striker. Andriy Shevchenko. my favorite participant. This was the first clip when I dreamed about my hereafter. seeing myself as a football star which is in no manner the state of affairs any longer. But I get in front of myself. I supported AC Milan till 28 May 2006. when Shevchenko left Milan for Chelsea. one of the nines I am least fond of even today. and I had to happen a new nine. It was so that I started back uping a Spanish nine. FC Barcelona. While everybody sought out Ronaldinho as their best participant. my favorite participant was a 19 twelvemonth old. Lionel Messi. I even remember holding written an article in originative composing naming him my graven image. and believing that one twenty-four hours he would go the world’s best participant. This portion about football might look irrelevant. but football has become such a important portion of my life that I couldn’t have perchance written an autobiography without including it. Bing a pupil of Sardar Patel Vidyalaya. I did non hold to confront the awfulness of tests till category 6th. I sometimes feel that deficiency of scrutinies may perchance be the ground why I remember so less about my surveies before category 6th. About a twelvemonth ago. while cleaning my room. I found a few books of category 5 every bit good as category 6. While I could retrieve the exact category for most of the scientific discipline chapter of category 6th. I could hardly make the same for the category 5 book. It might look a small uneven. but I think the lone possible account for this occurring is that I did non truly care much about my surveies till I entered category 6th. which I feel is a good thing. because my early childhood was a clip of great merriment! It was merely when I got to category 6th that I truly started to give much attending to my surveies. I must acknowledge it. I was haunted by the thought of scrutinies. I recall holding one time asked my parents how they used to rank in their category during school. merely to hear that they both had ever come in the top three. I knew by looking at his study cards. that the state of affairs of my brother was more or less the same. I do non cognize whether it was merely a instance of utmost captivation coupled with fright of non being able to fit to my parents’ criterions in scrutiny. but I could non halt believing about the thought of tests till I really gave my first test. I got full Markss in Mathematics. and came second in my subdivision ( I got to cognize my rank merely after inquiring most others their per centums ) . I can state for certain that I would hold been really delighted at that point of clip. After giving a twosome more tests. I came to the decision that it would be really hard to retrieve each and every thing that I study so hard on. and since I did non desire all my attempts to travel waste. I decided I would do notes after every test on whatever perchance I could hold done better. And now that I take my ticker to every test and get down fixing early etc. . this thought could reasonably be responsible for the rise in my per centum. I had been introduced to the thought of competitory tests at in-between school degree by my brother. and the idea was reinforced when my best friend Pratyush told me about the assorted tests organised by the Science Olympiad Foundation including the National Science Olympiad ( NSO ) and International Mathematics Olympiad ( IMO ) . Our school did non organize it for categories below 6th so I gave both of them for the first clip that really twelvemonth. I did non fix really hard for the test and hence got a really mean consequence. and that was when I asked my brother every bit good as Pratyush for some tips sing such tests. and when I was selected for the Ramanujan test in category 7th. I prepared hard this clip and ended up procuring a bronze decoration from among all pupils of Delhi /NCR. It was around this clip that I foremost heard about the National Talent Search Exam ( NTSE ) which was held for category 8th and is considered to be the most esteemed test at school degree. I was really aroused to give the test when I heard about the scholarship it offers and idea I would analyze for the following whole twelvemonth. the manner I had studied about a month before the old test I had given in my school. It was as if clip flew when I found myself holding finished the category 8th first semester tests. with about two months to travel for the first ( province ) degree of NTSE. I told my father- who had ever been an of import usher in all types of studies- that I felt it was excessively late and asked him whether it was deserving it for me to get down fixing now. At that clip he told me. and I quote It is neer excessively late’ . That line gave me the inspiration to travel for it and analyze for the following two months with all my might. I gave the first degree of the test and got ranked 42nd among the 50 pupils selected from Delhi. I was told that if I had qualified the first degree from Delhi. it was really improbable for me to non acquire selected in the 2nd degree. Even so. I had some sum of fright in myself. but I gathered all the finding in myself confidently gave the second degree every bit good as I could hold perchance given it. When the consequences came out. all three of the pupils from our school who had qualified in the first degree. including me and Pratyush. got selected. I ranked highest from our school and 95th All India. among the 1000 pupils selected for scholarship. I had neer seen my parents more proud of me than when I gave them this intelligence. I even retrieve seeing a tear in my mothers’ oculus. but I guess I am excessively immature to grok her feelings at that point. Between the first and 2nd degree of NTSE. I besides gave the Aryabhatta test and came foremost from our school and among the top 50 from Delhi. During these long hours of surveies. my concentration was frequently broken by day-to-day bhajans from the mandir right following to our house. Besides. our tip to Vaishno Devi in 2008 was non precisely a good experience. There were about 20 of us. and we had planned on traveling up to the mandir by a chopper and when all of us except for a household friend had reached. it was announced that the following flights had been cancelled due to the development of a storm. and finally he had to come up on horseback. We had to go all the manner up to the mandir and so back in the heaviest storm I have seen in my life. These two incidents along with the general disposition towards the Godhead in the Indian society made me inquire about his being. I had been taught the Hanuman Chalisa by my female parent and late my female parent had taught me to declaim the undermentioned lines whenever I need God to assist me: Nam Myoho Renge Kyo’ She had been taught this by my Maasi. who had late taken to Buddhism as a 2nd faith. These two things have ever helped me in life and I would ever thank God after every test I passed. or after the smallest of things in which I had asked for his aid. So. after traveling through 100s of pictures on Youtube. and holding questioned my maasi a figure of times. I came to the decision that there will neer be a scientific cogent evidence for the presence or absence of God. We can merely organize our ain sentiment about the Almighty. And I personally believe that there is a God out at that place who does everything for a ground. The ground might look to be inauspicious for some people at first. but it ever has a much greater good’ attached with it. A recent lesson larning event in my life was related to football. I have supported Barcelona of all time since. and it was a dream semen true when my male parent told me we are traveling to Spain for our trip this really twelvemonth. Before traveling to the trip. my male parent arranged for the tickets of a lucifer that was traveling to be held in Barcelona. I had neer been so aroused in my life than when I heard my male parent give me this astonishing intelligence. We foremost went to Madrid. and we visited the whole museum nowadays in the bowl of Barcelona’s rival nine. Real Madrid. I was evidently aroused thought that we would see the museum of the nine that I fancy the most every bit good. But when we got to Barcelona. I realised that there was no clip left at all for us to see the museum. The lone twenty-four hours possible was the twenty-four hours of the lucifer. but my male parent rejected my supplications as the household we had come with ( my bua’s household ) had thought of it as a twenty-four hours of remainder. When eventually the twenty-four hours arrived. it rained really to a great extent. and in no manner would it hold been possible for us to see the museum. That twenty-four hours I realised that one can non hold everything. and one needs to remain content with what one has. I went to the lucifer that twenty-four hours and enjoyed it more than anything else in my life. I ab initio thought of this undertaking to be nil but a sheer waste of clip. But now that I’ve finished it. I’ve come to gain that it was an experience through which I could understand my life and the forces that have shaped me. and lay a foundation for a much more hard and ambitious life yet to come. the journey of going a physician. It is merely now that the undermentioned quotation mark by Fernando Pessoa makes sense to me: Direct experience is an equivocation. or a hiding topographic point. for those without any imaginativeness. To narrate is to make. while to populate is simply to be lived.

History of the Australian Referendum during the 1967

History of the Australian Referendum during the 1967 Introduction The state of Australia before the referendum in 1967 was one related to a racist nation. During the year 1900, the British colonialists invaded Australia. To them, the nation was not habited and the aborigines, who lived in Australia, were part of the environment. The constitution that was drafted by the colonialists depicted high levels of inequalities (Crotty Roberts, 2009). The rights of the white settlers were highly upheld while those of the aborigines were diminishing.Advertising We will write a custom essay sample on History of the Australian Referendum during the 1967 specifically for you for only $16.05 $11/page Learn More Discussion During the 1967 referendum, various parts of the Australian constitution were questioned and changed. The first part was the one that stated who the commonwealth laws should govern (Attwood Markus, 2007). The constitution stated that commonwealth laws were only made for the whites and not the aborigines. It, therefore, implied that the aborigines had no constitutional rights under the commonwealth laws. The other section was the part that stated who should be counted during the national census. According to the 1900 constitution, the aborigines were not counted. The section was altered to give the aboriginal community an opportunity to be counted as part of the Australian citizens. So many people fought for a change in the Australian constitution. This act took them more than 10 years. The year 1967 was a major turning point in Australia as most of the people came out to vote for the alteration of the constitution. More than 90 percent of the populace voted in favour of the changes. The referendum was a breakthrough for the aboriginal people, who were counted later as part of the Australian citizens during the country’s population census. In addition, the aborigines came under the commonwealth statutes as opposed to the state regulations. The new constitution therefore was pa ssed on August 1967. The outcome of the referendum was of great benefit to the aborigines. First, it assisted in the removal of the initial rules of the aborigine act of 1905 that gave chief guardian of aborigines power over all aborigines up to the age of 16. The power of this guardian was much higher than that of a parent to her own child. The guardian could take children away from their families as he wish. These children were taken to the home of the white settlers or to some separate hostels. The parents were not informed on the whereabouts of their children, who, sometimes, were being subjected to torture. This act created some form of trauma for both parents and children as it at times involved some brutality. After the referendum, this role was scrubbed and it was a relief to the aborigines. The chief guardian also had control of the adult populace of aborigines. They were to seek permission for marriage; they did not have freedom of movement or right to own property. The ch anges of 1967 assured them these rights (Mason, Hill Davis, 2007).Advertising Looking for essay on political culture? Let's see if we can help you! Get your first paper with 15% OFF Learn More The new constitution also granted the aboriginal people the right to be Australian citizens. This right will ensure that they are not controlled by the aborigine’s act of 1905. The breakthrough of 1967 gave them this chance. The 1905 aborigines act allowed the aboriginal people to apply to be citizens of Australia so that they cannot be controlled by the act. The situation of the aboriginal people was to be improved through giving the people access to education, equal employment opportunities and contribute to the economy (Goot Rowse, 2007). They were to face a panel, which will assess their qualification for citizenship. Once it is granted, the chief protector had the ability to snatch it when he feels like. The changes in the constitution than more than 90 pe rcent of the population voted for showed that Australian people were tired of the existing racial discrimination. The event was worth celebrating, as it is a show of social equality, power lying on the people and a choice against discrimination (Attwood, Markus Schilling, 1997). This occurrence did not do away with the nature of ruling that existed in Australia. The government of Australia in most times forgot to seek advice from the aborigines on the ruling of the country. Now, the aboriginal populace still have a shorter life expectancy as compared to their non-indigenous counterparts. According to statistics, it is evident that the challenges of poor health, housing, education and high rates of unemployment are the main challenges facing the aborigines (Crotty Roberts, 2008). Despite the fact that the 1967 referendum was a breakthrough for the aborigines, there are times when it is clear that Australian community is fighting the battle of addressing fully the needs of the abori gines. The only impeccable period that showed that the Australians were concerned with the interests of the aborigines was during the referendum. There has been a moment of silence since the change of the Australian constitution. The forms of inequalities carried out by the constitution in silence have made the Australian people to look back to the evils that existed before the 1967 referendum. Conclusion The 1967 referendum did not bring about the end to racial discrimination that was in existence in Australia. It led to an improvement in the relationship between the aborigines and the entire Australian nation. The legacy that arose from the referendum is to some extent the most enduring (Tungate, 2007). The relationship that developed between the state and federal government became that of putting blame on one another. References Attwood, B., Markus, A., Schilling, K. (1997). The 1967 referendum, or,  When Aborigines didnt get the vote. Canberra: Aboriginal Studies Press.Advert ising We will write a custom essay sample on History of the Australian Referendum during the 1967 specifically for you for only $16.05 $11/page Learn More Attwood, B., Markus, A. (2007). The 1967 referendum: race, power and the Australian  Constitution (2nd ed.). Canberra: Aboriginal Studies Press. Crotty, M., Roberts, D. (2008). Turning Points in Australian History. Sydney: University of NSW Press. Crotty, M., Roberts, D. (2009). Turning points in Australian history. Sydney, N.S.W.: UNSW Press. Goot, M., Rowse, T. (2007). Divided Nation ?: Indigenous affairs and the imagined  public. Carlton: Melbourne University Press. Mason, K., Hill, K., Davis, R. (2007). Celebrating Aboriginal rights?: 16  July 7 September 2007, Tony Albert [et al.]. North Ryde: Macquarie University. Tungate, M. (2007). Adland: a global history of advertising. London: Kogan Page.

Blackberry Essay Example | Topics and Well Written Essays - 3000 words

Blackberry - Essay Example The reports will conclude with specific approaches for specific managerial problems providing clarity to the reader. Table of Contents Table of Contents 3 Discussion & Analysis 9 Managerial Decision Making 9 Conclusion 19 Recommendations 21 References 28 Introduction Blackberry is a popular handset device manufactured by the Research in Motion (RIM) headquartered in Waterloo. RIM had revolutionized the mobile industry with the introduction of the Blackberry handset in the year 1999 (Blackberry, 2013a).The launch of Blackberry products and services had changed the lifestyle and perception of the customers. The Blackberry handsets are multifunctional, offering services like capturing videos, games, music application, web browsing, emailing and other miscellaneous functions. The USP of the handset is that it offers instant messaging options to customers while maintaining a high level of security through message encryption and also serves the purpose of a multi digital functional assista nt. Recently, the company launched a tablet named The Blackberry Playbook (Blackberry, 2013b). The handset devices offer services like Enterprise Mobile Computing and Enterprise Mobility Management which enables the customers to utilize advanced technology and solve their problems. The blackberry technical services support system extends technical services and guidance to customers having problem in using the handset. The company’s stock is listed in NASDAQ and BBRY and the group is currently led by Mr. Thorsten Heins. The report highlights the various challenges faced by the management of Blackberry and the root cause of the problems. The author of the report will also provide remedial solutions which could have prevented the matter from aggravating further. The company has been facing severe technological, managerial and human resource challenges which will be highlighted in the report. The report will also highlight the various causes which led to downfall of the company a nd reduction in the market share. Finally, the report will conclude with suggestions that can help improve the existing strategic position of Blackberry. Background of the Problem The company’s popularity soared with the introduction of the Blackberry Pager and the Blackberry Pearl 8100. The pager become one of the most popular mobile handsets of and had attracted several customers. The CEO of Verizon communications was one of the first business enterprises had ordered RIM interactive pagers worth $70 million. The Blackberry Pearl phone was a unique phone which offered services like instant messaging, excellent camera features, smooth touch interface and other strong multimedia capabilities. The introduction of Blackberry Pearl 8100 was largely influenced by the emergence of Apple iPhone. Initially, the management of Blackberry did not consider the emergence of Apple iPhone as a threat due to its immense popularity however with the increase in the sales of Apple iPhone the ma nagement of Blackberry started considering Apple as serious threat. The sudden emergence of Apple in the mobile phone industry prompted the management of Blackberry to develop advanced phones like Blackberry Storm. Blackberry Storm was the first touch screen phone developed by Blackberry to attract potential customers. Blackberry had become a majority revenue contributor for RIM. However, the sales of the company started declining and the

TURING MACHINE Essay Example | Topics and Well Written Essays - 1500 words

TURING MACHINE - Essay Example In spite of its minimalism, a Turing machine could be modified to reproduce the logic of some computer algorithm, as well as this machine is mainly useful in illuminating the operations of a CPU within of a computer (Suber, 2002). This paper will present deep analysis of the different functionalities, operations, and uses of Turing machine. According to Weisstein (2009) the concept of the Turing machine was initially presented by Alan Turing in 1937. He also invented the initial Turing machine that was presented like an idealized model intended for mathematical computation. A Turing machine composed of a line of cells acknowledged as a "tape" that can be moved back as well as forth. In a Turing machine there is an active component "head" that has a feature acknowledged as "state" that is capable to transform the attribute recognized as "color" of the active cell below it, and also a set of commands for how the head needs to be adjusted by the active cell as well as shift the tape. In addition, the machine can transform the color of the Turing machine active cell at any step. Also, it can transform the position of the head, and moving the tape one step towards right or left (Weisstein, Turing Machine, 2009; Sipser, 2005). Copeland (2000), discusses about Universal Turing Machine (UTM), which is a Turing machine that is capable to replicate other Turing machine. An additional mathematically-oriented description by a related "universal" nature was presented by Alonzo Church, whose effort on lambda calculus linked with Turing in a prescribed hypothesis of computation identified as the Church–Turing theory. The theory presents that a Turing machines certainly holds the informal view of useful technique in mathematics as well as in logic, and also offers an accurate explanation of a mechanical procedure or algorithm (Copeland, 2000). According to Aanderaa (2006), a